|
KMID : 0379520170330020141
|
|
한국독성학회지
2017 Volume.33 No. 2 p.141 ~ p.147
|
|
|
Spontaneous Peripheral Ameloblastic Odontoma in a Male Sprague-Dawley Rat
|
|
Li Ying Hua
Bae Han-Ik
Kim Hak-Soo
Kang Min-Soo
Gong Bo-Ho
Jung Won-Hee
Lee Sranna
Bae Jin-Sook
Kim Kap-Ho
Song Si-Whan
Lee Jae-Hyun
Kang Boo-Hyon
|
|
|
Abstract
|
|
|
|
Peripheral ameloblastic odontoma is a rare variant of odontogenic tumor occurring in the extraosseous region. The present report describes a spontaneous tumor in male Sprague-Dawley (SD) rats. The clinically confirmed nodule in the right mandibular region was first observed when the rat was 42 weeks and remained until the terminal sacrifice date when the animal was 48 weeks of age. At necropsy, a well demarcated nodule, approximately 2.5 × 2.0 × 2.0 cm, protruded from the ventral area of the right mandible. The nodule was not attached to mandibular bone and was not continuous with the normal teeth. Histopathologically, the tumor was characterized by the simultaneous occurrence of an ameloblastomatous component and composite odontoma-like elements within the same tumor. The epithelial portion formed islands or cords resembling the follicle or plexiform pattern typical of ameloblastoma and was surrounded by mesenchymal tissue. Formation of eosinophilic and basophilic hard tissue matrix (dentin and enamel) resembling odontoma was observed in the center of the tumor. Mitotic figures were rare, and areas of cystic degeneration were present. Immunohistochemically, the epithelial component was positive for cytokeratin AE1/AE3 (CK AE1/AE3), and the mesenchymal component and odontoblast-like cells were positive for vimentin, in the same manner as in normal teeth. On the basis of these findings, the tumor was diagnosed as a peripheral ameloblastic odontoma in an extraosseous mandibular region in a SD rat. In the present study, we report the uncommon spontaneous peripheral ameloblastic odontoma in the SD rat. We also discuss here the morphological characteristics, origin, histochemical, and immunohistochemical features for the diagnosis of this tumor.
|
|
|
KEYWORD
|
|
|
Ameloblastoma, Odontogenic ectomesenchyme, Odontoma, Peripheral ameloblastic odontoma, Sprague-Dawley rat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|